Dr. Yeduguri Sandinti Rajasekhara Reddy (born 1949), is the Chief minister of Indian state of Andhra Pradesh. His nativity Pulivendula, a small town from Cuddapah district of the Rayalaseema region of Andhra Pradesh.

Dr.Reddy, belongs to Congress party and was elected to the Andhra Pradesh Legislative Assembly from the Pulivendula Assembly Constituency of Cuddapah District. He has been chief minister since May 14, 2004 . He served as the leader of opposition in the house for the previous term during which N. Chandrababu Naidu was the Chief Minster.

YSR is a medical science graduate from M.R.College of Gulbarga. He did his House-Surgency in SV Medical college, Tirupathi. Upon completion of his MBBS (Bachelor of Medicine and Bachelor of Surgery) degree, he served as Medical Officer at CSI Campbell Hospital , Jammalamadugu for a brief period of time. In 1973 he established a 70-bed charitable hospital at Pulivendula in the name of his father, Sri Y. S. Raja Reddy. The hospital continues to serve the poor till date.  

A doctor by profession, he made his debut in politics as a Youth Congress Leader. It is interesting fact to note that he and his present opponent TDP President Nara Chandrababu Naidu made their debut in the same time (1978) in Andhra Pradesh State Legislative Assembly as young legislators of the Congress party. They both worked together as ministers in Sri. Tanguturi Anjaiah's cabinet.

Dr.YSR has an active political career which spans over a quarter of a century to his record and has been representing his party on different fora. He was elected to Loksabha from Cuddapah constituency for four times and four times to Andhra Pradesh State Assembly from Pulivendula constituency. He twice served as the APCC President. He remains one of the very few national politicians, who never lost an election.